Blossom, Bubbles and Buttercup are bringing their world-saving superpowers to a computer near you on March 14.
Developed by award-winning studio Radian Games, Powerpuff Girls: Defenders of Townsville puts players in the flying shoes of the three heroes.
Mad monkey scientist Mojo Jojo stars as the game's bad guy, and the TV series' actresses lend their voices to the game's trio of girls.
From a video game's perspective, Radian's Luke Schneider cites Super Metroid -- which contains one of gaming's best examples of a strong female protagonist -- as well as Castlevania, Gunstar Heroes and Defender as key influences on the new tie-in.
Happily, Powerpuff Girls: Defenders of Townsville isn't just about keeping the siblings' city safe.
The Powerpuff deal helped save Radian from financial obscurity, even after a rich run of form that started with an entry to Microsoft's 2010 Dream Build Play competition and culminated in App Store favourites Slydris and Ballistic SE.
"It didn't hurt that Powerpuff Girls also happened to be my favourite Cartoon Network show, and I have two daughters that love superheroes," said Schneider, a veteran of PC and console hits "Saints Row: The Third" and "Red Faction: Guerrilla."
The game ties in to January TV special The Powerpuff Girls: Dance Pantsed, which introduced a new style to the series; accordingly, Defenders of Townsville features both the new and old look, as well as an extra-pixellated option for real retro fans.
Powerpuff Girls: Defenders of Townsville releases March 14 on Windows PC, Mac and Linux as a Steam Network download.
And if it does well on Steam, there's every chance it'll move onto the console platforms, too.